Ndor1^{Tg(UBC-cre/ERT2)1Ejb}
Transgenic Allele Detail

Summary

• Symbol: Ndor1^{Tg(UBC-cre/ERT2)1Ejb}
• Name: NADPH dependent diflavin oxidoreductase 1; transgene insertion 1, Eric J Brown
• MGI ID: MGI:3707333
• Synonyms: Cre-ER, Cre-ERT2, CreT2, hUBC-CreERT2, Tg(UBC-cre)1Ejb, Tg(UBC-cre/ERT2)1Ejb, Tg(UBC-cre/ESR1)1Ejb, Ubc-cre, Ubc-creER, UBC-Cre-ER-LBD-tg, Ubc-cre/ERT2, UBC-CreERt2, UBC-Cre^ERT2, UBC-CreER^T2
• Gene: Ndor1 Location: Chr2:25134825-25145458 bp, - strand Genetic Position: Chr2, 17.1 cM
• Alliance: Ndor1^{Tg(UBC-cre/ERT2)1Ejb} page

Transgene origin

• Strain of Origin: (129S/SvEv x C57BL/6)

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Ndor1^{Tg(UBC-cre/ERT2)1Ejb} expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  UBC (7316)

  Ubc	(MGI:98889)

• Mutation details: This Cre-ERT2 transgenic mouse line was generated via lentitransgenesis; a self-inactivating lentiviral vector was designed with the human ubiquitin C (UBC) promoter sequence upstream of a Cre-ERT2 fusion gene (Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain). Cre-ERT2-expressing lentivirus were microinjected into the perivitelline space of one-cell zygotes (129SvEv;C57BL/6 mixed genetic background). Mice display tamoxifen-inducible Cre activity in all tissue types. Line 1 inserted into the gene at 25249816-25249821 (Build GRCm38/mm10) resulting in a 5 bp deletion. (J:123200)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	UBC (human) Summary of all recombinase alleles driven by UBC. Comparative matrix view of recombinase activities Alliance human UBC gene page

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Ndor1^{Tg(UBC-cre/ERT2)1Ejb}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 6 strains available Cell Lines: 0 lines available
• Carrying any Ndor1 Mutation: 32 strains or lines available

References

• Original: J:123200 Ruzankina Y, et al., Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell. 2007 Jun 7;1(1):113-26
• All: 515 reference(s)