Plod1^tm1Soin
Targeted Allele Detail

Summary

• Symbol: Plod1^tm1Soin
• Name: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1; targeted mutation 1, Raija Soininen
• MGI ID: MGI:3712146
• Synonyms: Plod1^-
• Gene: Plod1 Location: Chr4:147994210-148021224 bp, - strand Genetic Position: Chr4, 78.57 cM
• Alliance: Plod1^tm1Soin page

Gait abnormalities in Plod1^tm1Soin/Plod1^tm1Soin mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120891
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The lacZ-neo reporter was fused in-frame to exon 2. Homologous recombination led to the deletion of exons 3-6 and fusion of the endogenous 129 bp 5' sequence into the bacterial beta-gal gene. RT-PCR confirmed absence of transcript in mutant heart. (J:120891)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plod1 Mutation: 28 strains or lines available

References

• Original: J:120891 Takaluoma K, et al., Tissue-specific changes in the hydroxylysine content and cross-links of collagens and alterations in fibril morphology in lysyl hydroxylase 1 knock-out mice. J Biol Chem. 2007 Mar 2;282(9):6588-96
• All: 3 reference(s)