Ightm2Mbu
Targeted Allele Detail
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Symbol: |
Ightm2Mbu |
Name: |
immunoglobulin heavy chain complex; targeted mutation 2, Meinrad Busslinger |
MGI ID: |
MGI:3719559 |
Synonyms: |
IghGFP |
Gene: |
Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic
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Germline Transmission: |
Earliest citation of germline transmission:
J:113322
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Null/knockout, Reporter) |
Mutations: |
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Deletion, Insertion
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Ightm2Mbu involves 1 genes/genome features (Igh)
View all
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Ightm2Mbu expresses
2 genes
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
CD2 (914) |
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human |
PAX5 (5079) |
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Mutation details: A vector containing human PAX5 cDNA interrupted by a floxed green fluorescent protein cDNA and a stop cassette, with the 3' end of PAX5 linked to human CD2 cDNA by an IRES, replaced Jh1-4 and DQ52 in these mutants.
(J:113322)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Igh Mutation: |
44 strains or lines available
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Original: |
J:113322 Delogu A, et al., Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells. Immunity. 2006 Mar;24(3):269-81 |
All: |
2 reference(s) |
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