Del(2Hoxd11-Hoxd13)27Ddu
Targeted Allele Detail

Summary

• Symbol: Del(2Hoxd11-Hoxd13)27Ddu
• Name: deletion, Chr 2, Denis Duboule 27
• MGI ID: MGI:3762143
• Synonyms: CreDel7, Del27Ddu, Hoxd^d11CreDel7
• Gene: Del(2Hoxd11-Hoxd13)27Ddu Location: Chr2:74498654-74517360 bp Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82530
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(2Hoxd11-Hoxd13)27Ddu involves 4 genes/genome features (Hoxd13, Hoxd12, Hoxd11 ...) View all
• Mutation details: These mice were generated by producing animals carrying the Evx2/Hoxd1^tm4Ddu allele and another targeted Hoxd allele Hoxd^tm5Ddu which has a loxP site between Hoxd11 and Hoxd10. Cre recombinase was introduced via the Tg(Sycp1-cre)4Min transgene, resulting in a crossing over between the loxP sites in the two alleles during meiotic prophase, inducing deletion of Hoxd11, Hoxd12, and Hoxd13. The Hoxd11/cre sequence is now located in the original genomic position of the deleted endogenous Hoxd11 locus. (J:82530)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(2Hoxd11-Hoxd13)27Ddu Mutation: 1 strain or line available

References

• Original: J:82530 Herault Y, et al., A nested deletion approach to generate Cre deleter mice with progressive Hox profiles. Int J Dev Biol. 2002;46(1 Spec No):185-91
• All: 1 reference(s)