Ctnnb1^tm1Knw
Targeted Allele Detail

Summary

• Symbol: Ctnnb1^tm1Knw
• Name: catenin beta 1; targeted mutation 1, Barbara B Knowles
• MGI ID: MGI:3767601
• Synonyms: betaCatC^f
• Gene: Ctnnb1 Location: Chr9:120762466-120789573 bp, + strand Genetic Position: Chr9, 72.19 cM
• Alliance: Ctnnb1^tm1Knw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232771
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A targeting construct was used to flank exons 8 to 13 with loxP sites and insert an FRT-flanked NEO cassette into intron 13. The loxP flanked region is designed to remove amino acids 361 to 692, which encompasses a part of armadillo repeat 6 to a part of the C terminus. (J:232771)

Expression

In Mice Carrying this Mutation:

26 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ctnnb1 Mutation: 49 strains or lines available

Notes

ES cell line #693 (C57BL/6J-693).

References

• Original: J:232771 Messerschmidt D, et al., beta-catenin-mediated adhesion is required for successful preimplantation mouse embryo development. Development. 2016 Jun 1;143(11):1993-9
• All: 12 reference(s)