Tgfb3^tm1(cre)Vk
Targeted Allele Detail

Summary

• Symbol: Tgfb3^tm1(cre)Vk
• Name: transforming growth factor, beta 3; targeted mutation 1, Vesa Kaartinen
• MGI ID: MGI:3768673
• Synonyms: Tgfb3-Cre
• Gene: Tgfb3 Location: Chr12:86103519-86125815 bp, - strand Genetic Position: Chr12, 40.09 cM
• Alliance: Tgfb3^tm1(cre)Vk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128938
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Tgfb3^tm1(cre)Vk expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tgfb3 (MGI:98727)

• Mutation details: A promoterless Cre gene and a neomycin-resistant gene replaced the start site within exon 1. Cre expression was detected in the prefusion palatal epithelium. (J:128938)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tgfb3 (mouse) Summary of all recombinase alleles driven by Tgfb3. Comparative matrix view of recombinase activities Alliance mouse Tgfb3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tgfb3 Mutation: 35 strains or lines available

References

• Original: J:128938 Yang LT, et al., Tgfb1 expressed in the Tgfb3 locus partially rescues the cleft palate phenotype of Tgfb3 null mutants. Dev Biol. 2007 Dec 1;312(1):384-95
• All: 10 reference(s)