About   Help   FAQ
Il2rgtm2Cgn
Targeted Allele Detail
Summary
Symbol: Il2rgtm2Cgn
Name: interleukin 2 receptor, gamma chain; targeted mutation 2, University of Cologne
MGI ID: MGI:3776426
Synonyms: Il2rgflox
Gene: Il2rg  Location: ChrX:100307991-100311861 bp, - strand  Genetic Position: ChrX, 43.9 cM
Alliance: Il2rgtm2Cgn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:22521
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted into intron 1 and a loxP-flanked neomycin resistance cassette was placed into intron 6. After transient expression of Cre recombinase, ES cells with deletion of just the neo cassette were selected. Mice derived from these cells have loxP sites flanking exons 2 through 6, which encode the extracellular and transmembrane domains of the protein (J:22521)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il2rg Mutation:  178 strains or lines available
References
Original:  J:22521 DiSanto JP, et al., Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. Proc Natl Acad Sci U S A. 1995 Jan 17;92(2):377-81
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory