Gp1bb^tm1Frla
Targeted Allele Detail

Summary

• Symbol: Gp1bb^tm1Frla
• Name: glycoprotein Ib, beta polypeptide; targeted mutation 1, Francois Lanza
• MGI ID: MGI:3793296
• Synonyms: GPIbbeta^-
• Gene: Gp1bb Location: Chr16:18439069-18441153 bp, - strand Genetic Position: Chr16, 11.53 cM
• Alliance: Gp1bb^tm1Frla page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135065
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced with a neo cassette. The absence of protein product was confirmed by western blot analysis on platelet extracts. (J:135065)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gp1bb Mutation: 2 strains or lines available

References

• Original: J:135065 Strassel C, et al., Decreased thrombotic tendency in mouse models of the Bernard-Soulier syndrome. Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):241-7
• All: 4 reference(s)