Ebi3^Gt716Lex
Gene trapped Allele Detail

Summary

• Symbol: Ebi3^Gt716Lex
• Name: Epstein-Barr virus induced gene 3; gene trap 716, Lexicon Genetics
• MGI ID: MGI:3793965
• Synonyms: EBI3^-
• Gene: Ebi3 Location: Chr17:56259640-56264022 bp, + strand Genetic Position: Chr17, 29.08 cM
• Alliance: Ebi3^Gt716Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134148
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap vector VICTOR23 containing an IRES/beta-geo/puro cassette was inserted into intron 3. The absence of protein product was confirmed by western blot analysis on bone marrow-derived dendritic cell extracts. This is a null allele, reporter allele and gene trapped allele. (J:134148)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ebi3 Mutation: 12 strains or lines available

References

• Original: J:134148 Yang J, et al., Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgammat. Eur J Immunol. 2008 May;38(5):1204-14
• All: 5 reference(s)