Ace2^tm1Hira
Targeted Allele Detail

Summary

• Symbol: Ace2^tm1Hira
• Name: angiotensin converting enzyme 2; targeted mutation 1, Hiromi Rakugi
• MGI ID: MGI:3794966
• Gene: Ace2 Location: ChrX:162922338-162971414 bp, + strand Genetic Position: ChrX, 76.12 cM, cytoband F5
• Alliance: Ace2^tm1Hira page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135766
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a neo cassette. The absence of protein product was confirmed by westen blot analysis. (J:135766)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ace2 Mutation: 66 strains or lines available

References

• Original: J:135766 Yamamoto K, et al., Deletion of angiotensin-converting enzyme 2 accelerates pressure overload-induced cardiac dysfunction by increasing local angiotensin II. Hypertension. 2006 Apr;47(4):718-26
• All: 12 reference(s)