Alox12b^tm1Krie
Targeted Allele Detail

Summary

• Symbol: Alox12b^tm1Krie
• Name: arachidonate 12-lipoxygenase, 12R type; targeted mutation 1, Peter Krieg
• MGI ID: MGI:3795934
• Synonyms: Alox12b^flox
• Gene: Alox12b Location: Chr11:69047898-69060617 bp, + strand Genetic Position: Chr11, 42.38 cM
• Alliance: Alox12b^tm1Krie page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134709
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A tk/neo selection cassette flanked by two loxP sites was inserted 230 bp upstream of exon 8 replacing a 222-bp genomic sequence. A third loxP site was inserted 84 bp downstream of exon 8. (J:134709)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Alox12b Mutation: 38 strains or lines available

References

• Original: J:134709 Epp N, et al., 12R-lipoxygenase deficiency disrupts epidermal barrier function. J Cell Biol. 2007 Apr 9;177(1):173-82
• All: 2 reference(s)