Crybb2⁰³⁷⁷
Chemically induced Allele Detail

Summary

• Symbol: Crybb2⁰³⁷⁷
• Name: crystallin, beta B2; mutant line 0377
• MGI ID: MGI:3796239
• Synonyms: 0377^-, O377
• Gene: Crybb2 Location: Chr5:113206124-113217983 bp, - strand Genetic Position: Chr5, 55.38 cM
• Alliance: Crybb2⁰³⁷⁷ page

Mutation origin

• Strain of Origin: C3H/El

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis resulted in a nucleotide substitution of A to T at the end of intron 5 that reduces the effectiveness of the splice acceptor site and leads to the insertion of 57 bp at the beginning of exon 6. The inserted base pairs add 19 amino acids to the coded protein and produce an additional loop near the carboxyl terminus. (J:136138)
• Inheritance: Dominant

Expression

In Mice Carrying this Mutation:	40 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crybb2 Mutation: 13 strains or lines available

References

• Original: J:136138 Ganguly K, et al., Novel allele of crybb2 in the mouse and its expression in the brain. Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1533-41
• All: 4 reference(s)