Ifih1^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Ifih1^tm1Aki
• Name: interferon induced with helicase C domain 1; targeted mutation 1, Shizuro Akira
• MGI ID: MGI:3801032
• Synonyms: MDA5^-
• Gene: Ifih1 Location: Chr2:62426142-62476599 bp, - strand Genetic Position: Chr2, 35.85 cM, cytoband C3
• Alliance: Ifih1^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137522
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 containing the DExD/H box were replaced with a neo cassette. The absence of protein product was confirmed by western blot analysis on mouse embryonic fibroblast extracts. (J:137522)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ifih1 Mutation: 45 strains or lines available

References

• Original: J:137522 Kato H, et al., Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature. 2006 May 4;441(7089):101-5
• All: 27 reference(s)