Del(7Ifitm5-Ifitm6)1Masu
Targeted Allele Detail

Summary

• Symbol: Del(7Ifitm5-Ifitm6)1Masu
• Name: deletion, Chr 7, M Azim Surani 1
• MGI ID: MGI:3804041
• Synonyms: Del1Masu, IfitmDel
• Gene: Del(7Ifitm5-Ifitm6)1Masu Location: Chr7:140528875-140596805 bp Genetic Position: Chr7, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137940
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(7Ifitm5-Ifitm6)1Masu involves 6 genes/genome features (Ifitm5, Ifitm2, Ifitm1 ...) View all
• Mutation details: Targeting using MICE vectors inserted a loxP site centromeric to Ifitm5 and another loxP site telomeric to Ifitm6. Transient cre expression in ES cells was used to remove 120 kb genomic region between the two genes that includes Ifitm5, Ifitm2, Ifitm1, Ifitm3 and Ifitm6. (J:137940)

Expression

In Mice Carrying this Mutation:

42 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(7Ifitm5-Ifitm6)1Masu Mutation: 1 strain or line available

References

• Original: J:137940 Lange UC, et al., Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster. Mol Cell Biol. 2008 Aug;28(15):4688-96
• All: 8 reference(s)