Ins2^tm1.1Nagy
Targeted Allele Detail

Summary

• Symbol: Ins2^tm1.1Nagy
• Name: insulin II; targeted mutation 1.1, Andras Nagy
• MGI ID: MGI:3807183
• Synonyms: I2loxP, Ins2^I2loxP
• Gene: Ins2 Location: Chr7:142232393-142233463 bp, - strand Genetic Position: Chr7, 88.0 cM
• Alliance: Ins2^tm1.1Nagy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130399
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene with a polyadenylation signal, but having a single loxP site in place of a promoter (loxP-neo-pA), resides 2.6 kb upstream of (distal to) and in the same transcriptional orientation as the insulin 2 gene on Chromosome (Chr) 7, between the domain of influence of Chr 7 imprinting center (IC) 1 (H19 DMR) and that of IC2 (KvDMR1). (J:130399)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ins2 Mutation: 93 strains or lines available

References

• Original: J:130399 Oh R, et al., Epigenetic and phenotypic consequences of a truncation disrupting the imprinted domain on distal mouse chromosome 7. Mol Cell Biol. 2008 Feb;28(3):1092-103
• All: 3 reference(s)