Batf3^tm1Kmm
Targeted Allele Detail

Summary

• Symbol: Batf3^tm1Kmm
• Name: basic leucine zipper transcription factor, ATF-like 3; targeted mutation 1, Kenneth M Murphy
• MGI ID: MGI:3817232
• Gene: Batf3 Location: Chr1:190830611-190841140 bp, + strand Genetic Position: Chr1, 96.28 cM, cytoband H6
• Alliance: Batf3^tm1Kmm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141064
• Parent Cell Line: MC50 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-2 were replaced by a floxed neomycin cassette. Cre-mediated recombination removed the neo cassette. Gene inactivation was confirmed by a lack of protein detected by immunoblot analysis of Th1 CD4⁺ T cells. (J:141064)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Batf3 Mutation: 18 strains or lines available

References

• Original: J:141064 Hildner K, et al., Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. Science. 2008 Nov 14;322(5904):1097-100
• All: 248 reference(s)