Trp73^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Trp73^tm1Mak
• Name: transformation related protein 73; targeted mutation 1, Tak Mak
• MGI ID: MGI:3822523
• Synonyms: TAp73^-
• Gene: Trp73 Location: Chr4:154140706-154224332 bp, - strand Genetic Position: Chr4, 83.79 cM
• Alliance: Trp73^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142848
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with a floxed neo cassette. The absence of protein expression of all four TAp73 isoforms was confirmed by western blot analysis on ovary extracts. The deltaNp73 isoforms are expressed. (J:142848)

Expression

In Mice Carrying this Mutation:	5 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Trp73^tm1Mak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Trp73 Mutation: 46 strains or lines available

References

• Original: J:142848 Tomasini R, et al., TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev. 2008 Oct 1;22(19):2677-91
• All: 19 reference(s)