Fgfr3^tm1.1Aomw
Targeted Allele Detail

Summary

• Symbol: Fgfr3^tm1.1Aomw
• Name: fibroblast growth factor receptor 3; targeted mutation 1.1, Andrew O M Wilkie
• MGI ID: MGI:3831364
• Synonyms: Fgfr3^P244R
• Gene: Fgfr3 Location: Chr5:33879068-33894412 bp, + strand Genetic Position: Chr5, 17.83 cM, cytoband B
• Alliance: Fgfr3^tm1.1Aomw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144356
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Insertion
• Mutation details: A point mutation changing a C to G at position 731 in exon 7 (P244R) and a floxed neo cassette in intron 7 were introduced by homologous recombination. The neo cassette was then removed by Cre mediated recombination. (J:144356)

Disease models

Expression

In Structures Affected by this Mutation:

19 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Fgfr3 Mutation: 54 strains or lines available

References

• Original: J:144356 Twigg SR, et al., Skeletal analysis of the Fgfr3(P244R) mouse, a genetic model for the Muenke craniosynostosis syndrome. Dev Dyn. 2009 Feb;238(2):331-42
• All: 5 reference(s)