Traf6^tm1.1Mpa
Targeted Allele Detail

Summary

• Symbol: Traf6^tm1.1Mpa
• Name: TNF receptor-associated factor 6; targeted mutation 1.1, Manolis Pasparakis
• MGI ID: MGI:3836555
• Synonyms: TRAF6^flox
• Gene: Traf6 Location: Chr2:101508774-101532014 bp, + strand Genetic Position: Chr2, 53.9 cM
• Alliance: Traf6^tm1.1Mpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145306
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neomycin resistance cassette. (J:202191)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Traf6 Mutation: 34 strains or lines available

References

• Original: J:145306 Imai Y, et al., Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell. 2008 Apr 18;133(2):235-49
• All: 11 reference(s)