Tg(Hspa2-cre)1Eddy
Transgene Detail

Summary

• Symbol: Tg(Hspa2-cre)1Eddy
• Name: transgene insertion 1, Edward M Eddy
• MGI ID: MGI:3843498
• Synonyms: Hspa2-cre, Hspa2^cre, Hspa2-cre line 54
• Transgene: Tg(Hspa2-cre)1Eddy Location: unknown
• Alliance: Tg(Hspa2-cre)1Eddy page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Hspa2-cre)1Eddy expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hspa2 (MGI:96243)

• Mutation details: The Hspa2-Cre transgene was designed with (from 5' to 3') a 53 bp mouse Acrv1 (acrosomal vesicle protein 1 [SP-10]) insulator element, a promoter element from the mouse Hspa2 locus (heat shock protein 2 [Hsp70-2]); containing the ATG start site and 892 bp of immediately upstream sequence), a 275 bp fragment of the cre gene, the bovine growth hormone 3' UTR and polyA sequence, and another 53 bp mouse Acrv1 insulator element. This transgene was injected into C57BL/6 pronuclear stage embryos. Expression of Cre recombinase is directed to the developing male germ cells. (J:148085, J:156314)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hspa2 (mouse) Summary of all recombinase alleles driven by Hspa2. Comparative matrix view of recombinase activities Alliance mouse Hspa2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:156314 Inselman AL, et al., Heat shock protein 2 promoter drives cre expression in spermatocytes of transgenic mice. Genesis. 2010 Feb;48(2):114-20
• All: 19 reference(s)