Atm^tm2.1Fwa
Targeted Allele Detail

Summary

• Symbol: Atm^tm2.1Fwa
• Name: ataxia telangiectasia mutated; targeted mutation 2.1, Frederick W Alt
• MGI ID: MGI:3851145
• Synonyms: Atm^c
• Gene: Atm Location: Chr9:53350449-53448040 bp, - strand Genetic Position: Chr9, 29.12 cM, cytoband C-D
• Alliance: Atm^tm2.1Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150435
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Intragenic deletion
• Mutation details: Sequence encoding the core PIKK kinase domain of the protein protein product were floxed by placing a loxP site upstream of exon 57 and floxed neomycin cassette downstream of exon 58. The neomycin cassette was subsequently removed by transient infection of cre recombinase. (J:138190)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Atm^tm2.1Fwa

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Atm Mutation: 170 strains or lines available

References

• Original: J:150435 Callen E, et al., Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Mol Cell. 2009 May 15;34(3):285-97
• All: 27 reference(s)