Il2^m1
Spontaneous Allele Detail

Summary

• Symbol: Il2^m1
• Name: interleukin 2; mutation 1
• MGI ID: MGI:4352594
• Gene: Il2 Location: Chr3:37174862-37180103 bp, - strand Genetic Position: Chr3, 18.3 cM, cytoband B-C
• Alliance: Il2^m1 page

Mutation origin

• Strain of Origin: multiple strains

Mutation description

• Allele Type: Spontaneous
• Mutation: Undefined
• Mutation details: This hypoactive polymorphism, found in MRL/MpJ, SJL/J, and NOD/ShiLtJ inbred strains, includes a smaller polyglutamine tract predicted to shorten the first alpha helix, which forms part of the IL2 receptor binding site. (J:75331)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 8 strains available Cell Lines: 0 lines available
• Carrying any Il2 Mutation: 43 strains or lines available

References

• Original: J:75331 Choi Y, et al., Hypo-active variant of IL-2 and associated decreased T cell activation contribute to impaired apoptosis in autoimmune prone MRL mice. Eur J Immunol. 2002 Mar;32(3):677-85
• All: 3 reference(s)