Mir96^Dmdo
Chemically induced Allele Detail

Summary

• Symbol: Mir96^Dmdo
• Name: microRNA 96; diminuendo
• MGI ID: MGI:4354110
• Synonyms: DEA12, diminuendo, Dmdo
• Gene: Mir96 Location: Chr6:30169445-30169550 bp, - strand Genetic Position: Chr6, 12.52 cM
• Alliance: Mir96^Dmdo page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU induces an A to T transversion in the seed region resulting in transcript destabilization and translational inhibition. An additional mutation (C to T) was identified in exon 5 of Akr1b10. However, it does not alter the codon and is not thought to cause the phenotype associated with this mutant. (J:151354)
• Inheritance: Semidominant

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mir96 Mutation: 8 strains or lines available

References

• Original: J:151354 Lewis MA, et al., An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice. Nat Genet. 2009 May;41(5):614-8
• All: 7 reference(s)