Slc52a3^{tm2a(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Slc52a3^{tm2a(KOMP)Wtsi}
• Name: solute carrier protein family 52, member 3; targeted mutation 2a, Wellcome Trust Sanger Institute
• MGI ID: MGI:4363008
• Synonyms: Slc52a3-
• Gene: Slc52a3 Location: Chr2:151838431-151851178 bp, + strand Genetic Position: Chr2, 74.83 cM, cytoband H1
• Alliance: Slc52a3^{tm2a(KOMP)Wtsi} page
• IMPC: Slc52a3 gene page

Mutation origin

• Mutant Cell Lines: EPD0031_1_A07, EPD0031_1_A09, EPD0031_1_C09, EPD0031_1_D09, EPD0031_1_E08, EPD0031_1_F07, EPD0031_1_F08, EPD0031_1_G07, EPD0031_1_H07, EPD0031_1_H08
• Germline Transmission: Earliest citation of germline transmission: J:175295
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_gt0
• Mutation details: The L1L2_gt0 cassette was inserted at position 151845503 of Chromosome 2 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 151846888. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534, J:236029)

Expression

In Mice Carrying this Mutation:	34 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 1 line available
• Carrying any Slc52a3 Mutation: 27 strains or lines available

References

• Original: J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009
• All: 7 reference(s)