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Dctn5tm2a(KOMP)Wtsi
Targeted Allele Detail
Summary
Symbol: Dctn5tm2a(KOMP)Wtsi
Name: dynactin 5; targeted mutation 2a, Wellcome Trust Sanger Institute
MGI ID: MGI:4363526
Gene: Dctn5  Location: Chr7:121732264-121748267 bp, + strand  Genetic Position: Chr7, 65.47 cM, cytoband F3
Alliance: Dctn5tm2a(KOMP)Wtsi page
IMPC: Dctn5 gene page
Mutation
origin
Mutant Cell Lines:  EPD0064_2_A04, EPD0064_2_A05, EPD0064_2_A06, EPD0064_2_B04, EPD0064_2_B05, EPD0064_2_B06, EPD0064_2_C05, EPD0064_2_D04, EPD0064_2_E06, EPD0064_2_F04, EPD0064_2_F05, EPD0064_2_F06, EPD0064_2_G06, EPD0064_2_H04, EPD0064_2_H05
Germline Transmission:  Earliest citation of germline transmission: J:175295
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt2
 
Mutation detailsThe L1L2_gt2 cassette was inserted at position 121737017 of Chromosome 7 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 121737840. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dctn5 Mutation:  19 strains or lines available
References
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory