Fgf10^Mhdaaey17
Chemically induced Allele Detail

Summary

• Symbol: Fgf10^Mhdaaey17
• Name: fibroblast growth factor 10; Martin Hrabe de Angelis abnormalities of the eye 17
• MGI ID: MGI:4398706
• Synonyms: abnormalities of the eye 17, Aey17, Fgf10^Aey17, Fgf10^Gsfaey17, gsf abnormal eyes 17, Gsfaey17
• Gene: Fgf10 Location: Chr13:118851199-118928651 bp, + strand Genetic Position: Chr13, 67.14 cM, cytoband A3-A4
• Alliance: Fgf10^Mhdaaey17 page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU induces an A to G transition that destroys the splice signal. This mutation results in the inclusion of 49 bp from the 3' end of intron 1 and protein truncation after 54 new amino acids (p.S110TfsX55). (J:154551)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgf10 Mutation: 33 strains or lines available

References

• Original: J:154551 Puk O, et al., A new Fgf10 mutation in the mouse leads to atrophy of the harderian gland and slit-eye phenotype in heterozygotes: a novel model for dry-eye disease?. Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4311-8
• All: 2 reference(s)