Calcoco2^{tm1(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Calcoco2^{tm1(KOMP)Wtsi}
• Name: calcium binding and coiled-coil domain 2; targeted mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:4419466
• Gene: Calcoco2 Location: Chr11:95990152-96002790 bp, - strand Genetic Position: Chr11, 59.4 cM, cytoband C
• Alliance: Calcoco2^{tm1(KOMP)Wtsi} page
• IMPC: Calcoco2 gene page

Mutation origin

• Mutant Cell Lines: EPD0392_6_A09, EPD0392_6_A10, EPD0392_6_B10, EPD0392_6_C10, EPD0392_6_D10, EPD0392_6_D11, EPD0392_6_E09, EPD0392_6_E10, EPD0392_6_E12, EPD0392_6_F10, EPD0392_6_F11
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 5027 starting at position 95993439 and ending at position 95998466 of Chromosome 11 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:148605, J:173534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 1 line available
• Carrying any Calcoco2 Mutation: 40 strains or lines available

References

• Original: J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009
• All: 5 reference(s)