Apex1tm1(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Apex1tm1(KOMP)Wtsi |
Name: |
apurinic/apyrimidinic endonuclease 1; targeted mutation 1, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:4431417 |
Gene: |
Apex1 Location: Chr14:51162425-51164596 bp, + strand Genetic Position: Chr14, 26.3 cM, cytoband C3
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IMPC: |
Apex1 gene page |
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Mutant Cell Lines: |
EPD0468_3_A06, EPD0468_3_B05, EPD0468_3_B08, EPD0468_3_C05, EPD0468_3_D08, EPD0468_3_E05, EPD0468_3_E06, EPD0468_3_E07, EPD0468_3_E08, EPD0468_3_F05, EPD0468_3_F06, EPD0468_3_F07, EPD0468_3_G05, EPD0468_3_G06, EPD0468_3_G08 |
Germline Transmission: |
Unknown
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Parent Cell Line: |
JM8A3.N1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
Vector: L1L2_Bact_P
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Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 283 starting at position 51162919 and ending at position 51163202 of Chromosome 14 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site.
(J:148605, J:173534)
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Original: |
J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009; |
All: |
2 reference(s) |
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