Yy1^{tm1a(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Yy1^{tm1a(EUCOMM)Wtsi}
• Name: YY1 transcription factor; targeted mutation 1a, Wellcome Trust Sanger Institute
• MGI ID: MGI:4431729
• Gene: Yy1 Location: Chr12:108758899-108786074 bp, + strand Genetic Position: Chr12, 59.58 cM
• IMPC: Yy1 gene page

Mutation origin

• Mutant Cell Lines: EPD0298_1_A01, EPD0298_1_A02, EPD0298_1_A05, EPD0298_1_A06, EPD0298_1_A07, EPD0298_1_A08, EPD0298_1_A10, EPD0298_1_A11, EPD0298_1_A12, EPD0298_1_B01, EPD0298_1_B02, EPD0298_1_B03, EPD0298_1_B05, EPD0298_1_B06, EPD0298_1_B07, EPD0298_1_B09, EPD0298_1_B10, EPD0298_1_B11, EPD0298_1_B12, EPD0298_1_C01, EPD0298_1_C02, EPD0298_1_C04, EPD0298_1_C05, EPD0298_1_C06, EPD0298_1_C07, EPD0298_1_C09, EPD0298_1_C10, EPD0298_1_C11, EPD0298_1_C12, EPD0298_1_D01, EPD0298_1_D02, EPD0298_1_D03, EPD0298_1_D04, EPD0298_1_D05, EPD0298_1_D06, EPD0298_1_D07, EPD0298_1_D08, EPD0298_1_D09, EPD0298_1_D10, EPD0298_1_D11, EPD0298_1_D12, EPD0298_1_E02, EPD0298_1_E04, EPD0298_1_E05, EPD0298_1_E06, EPD0298_1_E07, EPD0298_1_E08, EPD0298_1_E09, EPD0298_1_E10, EPD0298_1_E11, EPD0298_1_E12, EPD0298_1_F03, EPD0298_1_F04, EPD0298_1_F05, EPD0298_1_F06, EPD0298_1_F07, EPD0298_1_F08, EPD0298_1_F09, EPD0298_1_F10, EPD0298_1_F11, EPD0298_1_F12, EPD0298_1_G01, EPD0298_1_G02, EPD0298_1_G04, EPD0298_1_G05, EPD0298_1_G06, EPD0298_1_G07, EPD0298_1_G09, EPD0298_1_G10, EPD0298_1_G11, EPD0298_1_H01, EPD0298_1_H03, EPD0298_1_H04, EPD0298_1_H05, EPD0298_1_H06, EPD0298_1_H07, EPD0298_1_H08, EPD0298_1_H09, EPD0298_1_H10, EPD0298_1_H11, EPD0298_1_H12
• Germline Transmission: Unknown
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_gt2
• Mutation details: The L1L2_gt2 cassette was inserted at position 108778419 of Chromosome 12 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 108779133. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Yy1 Mutation: 35 strains or lines available

References

• Original: J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010
• All: 2 reference(s)