Elk4^{tm1a(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Elk4^{tm1a(EUCOMM)Wtsi}
• Name: ELK4, member of ETS oncogene family; targeted mutation 1a, Wellcome Trust Sanger Institute
• MGI ID: MGI:4432021
• Gene: Elk4 Location: Chr1:131935129-131954186 bp, + strand Genetic Position: Chr1, 57.24 cM, cytoband E3-G
• Alliance: Elk4^{tm1a(EUCOMM)Wtsi} page
• IMPC: Elk4 gene page

Mutation origin

• Mutant Cell Lines: EPD0100_4_A06, EPD0100_4_A07, EPD0100_4_B08, EPD0100_4_C07, EPD0100_4_D05, EPD0100_4_D07, EPD0100_4_E05, EPD0100_4_E06, EPD0100_4_E07, EPD0100_4_F05, EPD0100_4_F07, EPD0100_4_G08
• Germline Transmission: Earliest citation of germline transmission: J:165965
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_gt0
• Mutation details: The L1L2_gt0 cassette was inserted at position 131944846 of Chromosome 1 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 131947480. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 1 line available
• Carrying any Elk4 Mutation: 17 strains or lines available

References

• Original: J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010
• All: 4 reference(s)