Herc1^{tm1e(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Herc1^{tm1e(EUCOMM)Wtsi}
• Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1; targeted mutation 1e, Wellcome Trust Sanger Institute
• MGI ID: MGI:4432036
• Gene: Herc1 Location: Chr9:66257732-66416057 bp, + strand Genetic Position: Chr9, 35.86 cM, cytoband D
• IMPC: Herc1 gene page

Mutation origin

• Mutant Cell Lines: EPD0027_1_A02, EPD0027_1_A03, EPD0027_1_B01, EPD0027_1_B02, EPD0027_1_C01, EPD0027_1_C02, EPD0027_1_D02, EPD0027_1_E02, EPD0027_1_E03, EPD0027_1_F02, EPD0027_1_G01, EPD0027_1_H02
• Germline Transmission: Unknown
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_st1
• Mutation details: The L1L2_st1 cassette was inserted at position 66298156 of Chromosome 9 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Herc1 Mutation: 209 strains or lines available

References

• Original: J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010
• All: 2 reference(s)