Epc2^{tm1e(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Epc2^{tm1e(EUCOMM)Wtsi}
• Name: enhancer of polycomb homolog 2; targeted mutation 1e, Wellcome Trust Sanger Institute
• MGI ID: MGI:4433594
• Gene: Epc2 Location: Chr2:49341498-49441954 bp, + strand Genetic Position: Chr2, 28.62 cM
• Alliance: Epc2^{tm1e(EUCOMM)Wtsi} page
• IMPC: Epc2 gene page

Mutation origin

• Mutant Cell Lines: EPD0018_2_A10, EPD0018_2_F12, EPD0018_2_G11, EPD0018_2_H12
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: JM8 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_gtk
• Mutation details: The L1L2_gtk cassette was inserted at position 49378209 of Chromosome 2 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Epc2 Mutation: 51 strains or lines available

References

• Original: J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010
• All: 4 reference(s)