Smurf1^{tm1e(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Smurf1^{tm1e(EUCOMM)Wtsi}
• Name: SMAD specific E3 ubiquitin protein ligase 1; targeted mutation 1e, Wellcome Trust Sanger Institute
• MGI ID: MGI:4433894
• Gene: Smurf1 Location: Chr5:144813305-144902657 bp, - strand Genetic Position: Chr5, 84.83 cM, cytoband G2
• IMPC: Smurf1 gene page

Mutation origin

• Mutant Cell Lines: EPD0102_3_A07, EPD0102_3_B09, EPD0102_3_C08, EPD0102_3_F07, EPD0102_3_H07
• Germline Transmission: Unknown
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_gt2
• Mutation details: The L1L2_gt2 cassette was inserted at position 144836782 of Chromosome 5 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Smurf1 Mutation: 55 strains or lines available

References

• Original: J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010
• All: 2 reference(s)