Dhcr24^{tm1e(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Dhcr24^{tm1e(EUCOMM)Wtsi}
• Name: 24-dehydrocholesterol reductase; targeted mutation 1e, Wellcome Trust Sanger Institute
• MGI ID: MGI:4434331
• Gene: Dhcr24 Location: Chr4:106418279-106446310 bp, + strand Genetic Position: Chr4, 49.67 cM, cytoband C7
• IMPC: Dhcr24 gene page

Mutation origin

• Mutant Cell Lines: EPD0058_3_A10, EPD0058_3_A12, EPD0058_3_D12, EPD0058_3_E12, EPD0058_3_G10, EPD0058_3_H10
• Germline Transmission: Unknown
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_st0
• Mutation details: The L1L2_st0 cassette was inserted at position 106428382 of Chromosome 4 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Dhcr24 Mutation: 35 strains or lines available

References

• Original: J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010
• All: 2 reference(s)