Slc38a10^{tm2a(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Slc38a10^{tm2a(EUCOMM)Wtsi}
• Name: solute carrier family 38, member 10; targeted mutation 2a, Wellcome Trust Sanger Institute
• MGI ID: MGI:4441779
• Gene: Slc38a10 Location: Chr11:119994786-120042172 bp, - strand Genetic Position: Chr11, 83.96 cM
• Alliance: Slc38a10^{tm2a(EUCOMM)Wtsi} page
• IMPC: Slc38a10 gene page

Mutation origin

• Mutant Cell Lines: EPD0023_1_A07, EPD0023_1_A08, EPD0023_1_B07, EPD0023_1_B08, EPD0023_1_C07, EPD0023_1_C09, EPD0023_1_D07, EPD0023_1_D08, EPD0023_1_D09, EPD0023_1_E07, EPD0023_1_E09, EPD0023_1_F07, EPD0023_1_F08, EPD0023_1_F09, EPD0023_1_G08, EPD0023_1_G09, EPD0023_1_H08
• Germline Transmission: Earliest citation of germline transmission: J:165965
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_gt0
• Mutation details: The L1L2_gt0 cassette was inserted at position 120038194 of Chromosome 11 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 120039136. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 1 line available
• Carrying any Slc38a10 Mutation: 34 strains or lines available

References

• Original: J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010
• All: 9 reference(s)