Ppp1r14c^tm1Uhl
Targeted Allele Detail

Summary

• Symbol: Ppp1r14c^tm1Uhl
• Name: protein phosphatase 1, regulatory inhibitor subunit 14C; targeted mutation 1, George R Uhl
• MGI ID: MGI:4450989
• Gene: Ppp1r14c Location: Chr10:3316057-3414975 bp, + strand Genetic Position: Chr10, 2.06 cM
• Alliance: Ppp1r14c^tm1Uhl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159561
• Parent Cell Line: MC1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 1 was replaced with a neo cassette. RT-PCR confirmed the absence of transcript expression. (J:159561)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ppp1r14c Mutation: 18 strains or lines available

Notes

The original line on a mixed 129S6/SvEvTac and C57BL/6 background was discontinued in favor of a recombinant line containing regions adjacent to the targeted allele from C57BL/6 (J:159561).

References

• Original: J:159561 Drgonova J, et al., Effect of KEPI (Ppp1r14c) deletion on morphine analgesia and tolerance in mice of different genetic backgrounds: when a knockout is near a relevant quantitative trait locus. Neuroscience. 2010 Feb 3;165(3):882-95
• All: 2 reference(s)