Grhl3tm2a(EUCOMM)Wtsi
Targeted Allele Detail
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Symbol: |
Grhl3tm2a(EUCOMM)Wtsi |
Name: |
grainyhead like transcription factor 3; targeted mutation 2a, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:4456786 |
Gene: |
Grhl3 Location: Chr4:135269199-135300941 bp, - strand Genetic Position: Chr4, 67.76 cM
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IMPC: |
Grhl3 gene page |
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Mutant Cell Lines: |
EPD0014_3_A04, EPD0014_3_A05, EPD0014_3_A06, EPD0014_3_B04, EPD0014_3_D05, EPD0014_3_E05, EPD0014_3_F05, EPD0014_3_F06, EPD0014_3_H04, EPD0014_3_H05 |
Germline Transmission: |
Unknown
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Parent Cell Line: |
AB2.2 (ES Cell)
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Strain of Origin: |
129S7/SvEvBrd-Hprt1b-m2
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Conditional ready, Null/knockout, Reporter) |
Mutation: |
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Insertion
Vector: L1L2_gt2
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Mutation details: The L1L2_gt2 cassette was inserted at position 135288157 of Chromosome 4 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 135289135. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:155845, J:173534)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Grhl3 Mutation: |
53 strains or lines available
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Original: |
J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010; |
All: |
2 reference(s) |
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