Trim3^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Trim3^tm1Mak
• Name: tripartite motif-containing 3; targeted mutation 1, Tak Mak
• MGI ID: MGI:4459821
• Gene: Trim3 Location: Chr7:105253670-105282778 bp, - strand Genetic Position: Chr7, 55.91 cM
• Alliance: Trim3^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161372
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Most of coding exons 2-5 were replaced with a neomycin resistance cassette by homologous recombination. Absence of protein was confirmed by western blot of protein lysates from the brain. (J:161372)

Generation of the Trim3^tm1Mak allele

Expression

In Mice Carrying this Mutation:

1 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trim3 Mutation: 37 strains or lines available

References

• Original: J:161372 Cheung CC, et al., Identification of BERP (brain-expressed RING finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABAA receptors. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11883-8
• All: 1 reference(s)