Dp(17Abcg1-Rrp1b)3Yey
Targeted Allele Detail

Summary

• Symbol: Dp(17Abcg1-Rrp1b)3Yey
• Name: duplication, Chr 17, Y Eugene Yu 3
• MGI ID: MGI:4461399
• Synonyms: Dp(17)1Yey, Dp(17Abcg1-Rrp1b)1Yey, Dp3Yey, Ts3Yey
• Gene: Dp(17Abcg1-Rrp1b)3Yey Location: Chr17:31276672-32281839 bp Genetic Position: Chr17, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161325
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Duplication
• Dp(17Abcg1-Rrp1b)3Yey involves 28 genes/genome features (Gm25447, Gm25883, Gm24970 ...) View all
• Mutation details: Cre mediated chromosomal rearrangement between loxP sites in regions proximal to Abcg1 and distal to Rrp1b results in duplication of the genes, including Abcg1 and Rrp1b, in this approximately 1.1 Mb region that is syntenic with the proximal part of human 21q22.3. (J:161325)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Dp(17Abcg1-Rrp1b)3Yey Mutation: 3 strains or lines available

References

• Original: J:161325 Yu T, et al., A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions. Hum Mol Genet. 2010 Jul 15;19(14):2780-91
• All: 19 reference(s)