Tg(Gcg-GH1)#Herr
Transgene Detail
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Symbol: |
Tg(Gcg-GH1)#Herr |
Name: |
transgene insertion, Pedro Luis Herrera |
MGI ID: |
MGI:4821341 |
Synonyms: |
GlucagonPr-loxP-STOP-loxP-hGH |
Transgene: |
Tg(Gcg-GH1)#Herr Location: unknown
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Alliance: |
Tg(Gcg-GH1)#Herr page
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Strain of Origin: |
(C57BL/6J x CBA/J)F2
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Transgene Type: |
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Transgenic (Reporter) |
Mutation: |
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Insertion
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Mutation details: The construct consisted of the 2.1 kb rat glucagon promoter, a loxP-STOP-loxP sequence and the human growth hormone gene (GH1; hGH). (C57BL/6J x CBA/J)F2 zygotes were injected and at least three founder lines were generated and a line with stable and complete transgene expression (i.e. in about 100% of targeted cells) was established. Crosses with cre-expressing animals will excise the STOP signal, resulting in GH1 expression as a tag.
(J:78865)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:78865 Herrera PL, Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development. 2000 Jun;127(11):2317-22 |
All: |
2 reference(s) |
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