Stat1^tm1Mam
Targeted Allele Detail

Summary

• Symbol: Stat1^tm1Mam
• Name: signal transducer and activator of transcription 1; targeted mutation 1, Lothar Hennighausen
• MGI ID: MGI:4821871
• Synonyms: Stat1 fl/fl
• Gene: Stat1 Location: Chr1:52158599-52201024 bp, + strand Genetic Position: Chr1, 26.81 cM
• Alliance: Stat1^tm1Mam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163376
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to place a loxP flanked neomycin resistance gene upstream of the first untranslated exon followed by a loxP site downstream of the first translated exon. The neo cassette was removed by germ-line cre-mediated resombination leaving loxP sites flanking the first two untranslated exons and the first translated exon. (J:163376)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stat1 Mutation: 74 strains or lines available

References

• Original: J:163376 Klover P, et al., Generation of a Stat1 conditional allele. MGI Direct Data Submission. 2010
• All: 34 reference(s)