Col4a1^Acso
Chemically induced Allele Detail

Summary

• Symbol: Col4a1^Acso
• Name: collagen, type IV, alpha 1; anterior capsular and suture opacity
• MGI ID: MGI:4822140
• Gene: Col4a1 Location: Chr8:11248423-11362826 bp, - strand Genetic Position: Chr8, 5.53 cM
• Alliance: Col4a1^Acso page

Mutation origin

• Strain of Origin: (101/El x C3H/El)F1

Mutation description

• Allele Type: Chemically induced (other)
• Mutation: Single point mutation
• Mutation details: Male hybrid mice were injected intraperitoneally with procarbazine hydrochloride. A G to A nucleotide substitution at position 2104 (NCBI accession # NM_009931) resulted in a glycine to aspartic acid substitution at amino acid residue 658. (J:163225)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Col4a1 Mutation: 78 strains or lines available

References

• Original: J:24033 Kratochvilova J, et al., Dominant cataract and recessive specific-locus mutations detected in offspring of procarbazine-treated male mice. Mutat Res. 1988 Apr;198(2):295-301
• All: 3 reference(s)