Tg(Thy1-PSEN1*A246E)16-3Sqn
Transgene Detail

Summary

• Symbol: Tg(Thy1-PSEN1*A246E)16-3Sqn
• Name: transgene insertion 16-3, Su Qian
• MGI ID: MGI:4836548
• Transgene: Tg(Thy1-PSEN1*A246E)16-3Sqn Location: unknown
• Alliance: Tg(Thy1-PSEN1*A246E)16-3Sqn page

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-PSEN1*A246E)16-3Sqn expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PSEN1 (5663)

  Psen1

  (MGI:1202717)

  Transgene codes for a protein with a alanine to glutamic acid mutation.

• Mutation details: The human Thy-1 promoter was used to drive expression of a presenilin cDNA containing a substitution encoding an A246E amino acid substitution. Four lines were examined for their ability to rescue phenotypic defects in presinilin deficient mice. Ability to rescue phenotype varied but line 16-3 was one of the better lines and was chosen as representative. (J:77306)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:77306 Qian S, et al., Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression. Neuron. 1998 Mar;20(3):611-7
• All: 2 reference(s)