Tg(Tcrb-LMR16.2)1Nglh
Transgene Detail

Summary

• Symbol: Tg(Tcrb-LMR16.2)1Nglh
• Name: transgene insertion 1, Nicolas Glaichenhaus
• MGI ID: MGI:4838256
• Synonyms: 16.2beta transgene
• Transgene: Tg(Tcrb-LMR16.2)1Nglh Location: unknown
• Alliance: Tg(Tcrb-LMR16.2)1Nglh page

Transgene origin

• Strain of Origin: (B10.S-H2^s/Sg x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tcrb-LMR16.2)1Nglh expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcrb (MGI:98578)

• Mutation details: This transgene encodes the rearranged T cell receptor beta chain of the LMR16.2 T cell hybridoma, derived from the Leishmania major specific TH1 clone 9.1-2, which recognizes the LACK (Leishmania homolog of receptors for activated C kinase) antigen expressed by both stages of the Leishmania parasite. (J:66562, J:165700)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:66562 Malherbe L, et al., Selective activation and expansion of high-affinity CD4+ T cells in resistant mice upon infection with Leishmania major. Immunity. 2000 Dec;13(6):771-82
• All: 4 reference(s)