Tg(ITGAM-TK)620Zbz
Transgene Detail

Summary

• Symbol: Tg(ITGAM-TK)620Zbz
• Name: transgene insertion 620, Universitatsspital Zurich, Biologisches Zentrallaboratorium
• MGI ID: MGI:4839616
• Synonyms: CD11b-HSVTK, tg620, Tg(CD11b-HSVTK)618Zbz
• Transgene: Tg(ITGAM-TK)620Zbz Location: unknown
• Alliance: Tg(ITGAM-TK)620Zbz page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The human ITGAM promoter drives expression of the Herpes Simplex Virus thymidine kinse gene. All macrophage-containing organs, including spleen, lung and brain, showed sustained expression of the HSVTK transgene. Transgene expression within the CNS was present in microglial cells but not in astrocytes. Administration of gancyclovir for 5-6 days results in the ablation of ITGAM-expressing cells. Line 618 was also created. (J:96037)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:96037 Heppner FL, et al., Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nat Med. 2005 Feb;11(2):146-52
• All: 11 reference(s)