Creb3l1^{tm1e(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Creb3l1^{tm1e(EUCOMM)Wtsi}
• Name: cAMP responsive element binding protein 3-like 1; targeted mutation 1e, Wellcome Trust Sanger Institute
• MGI ID: MGI:4842311
• Gene: Creb3l1 Location: Chr2:91812673-91854515 bp, - strand Genetic Position: Chr2, 50.63 cM, cytoband E1
• Alliance: Creb3l1^{tm1e(EUCOMM)Wtsi} page
• IMPC: Creb3l1 gene page

Mutation origin

• Mutant Cell Lines: EPD0651_2_A12, EPD0651_2_B03, EPD0651_2_B05, EPD0651_2_C01, EPD0651_2_C11, EPD0651_2_D01, EPD0651_2_D04, EPD0651_2_D09, EPD0651_2_D10, EPD0651_2_E04, EPD0651_2_E07, EPD0651_2_F05, EPD0651_2_F11, EPD0651_2_F12, EPD0651_2_G06, EPD0651_2_G10, EPD0651_2_H07
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 91832818 of Chromosome 2 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Creb3l1 Mutation: 56 strains or lines available

References

• Original: J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010
• All: 6 reference(s)