Gfi1^Gen
Chemically induced Allele Detail

Summary

• Symbol: Gfi1^Gen
• Name: growth factor independent 1 transcription repressor; Genista
• MGI ID: MGI:4881336
• Synonyms: Gen, Genista, Gfi1^Genista
• Gene: Gfi1 Location: Chr5:107864521-107873671 bp, - strand Genetic Position: Chr5, 52.23 cM
• Alliance: Gfi1^Gen page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU induces a point mutation in zinc finger domain III that results in the amino acid substitution of tyrosine for cysteine at position 318 (C318Y). (J:182679)
• Inheritance: Dominant

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gfi1 Mutation: 31 strains or lines available

References

• Original: J:182679 Jaeger BN, et al., Neutrophil depletion impairs natural killer cell maturation, function, and homeostasis. J Exp Med. 2012 Mar 12;209(3):565-80
• All: 12 reference(s)