Gt(ROSA)26Sor^{tm37(H1/tetO-RNAi:Tafazzin)Arte}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm37(H1/tetO-RNAi:Tafazzin)Arte}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 37, TaconicArtemis
• MGI ID: MGI:4887237
• Synonyms: Gt(ROSA)26Sor^{tm1(H1/tetO-RNAi:Taz,CAG-tetR)Bsf}, Gt(ROSA)26Sor^{tm37(H1/tetO-RNAi:Taz)Arte}, ROSA26^{H1/tetO-shRNA:taz}, TAZKD
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm37(H1/tetO-RNAi:Tafazzin)Arte} page

Defects of cardiac mitochondria and mitochondrion-associated membranes in Gt(ROSA)26Sor^{tm37(H1/tetO-RNAi:Tafazzin)Arte}/Gt(ROSA)26Sor⁺ mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167527
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Inducible, Knockdown)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm37(H1/tetO-RNAi:Tafazzin)Arte} involves 1 genes/genome features (Tafazzin) View all
• Mutation details: A short hairpin RNA directed against Taz was targeted into the Rosa26 locus. The shRNA sequence is under the regulation of the H1/tetO operator fusion promoter. Correct mRNA knock-down was confirmed in embryonic stem cells. (J:167527)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:167527 Acehan D, et al., Cardiac and skeletal muscle defects in a mouse model of human barth syndrome. J Biol Chem. 2011 Jan 14;286(2):899-908
• All: 41 reference(s)