Thpo^{tm1.1(TPO)Flv}
Targeted Allele Detail

Summary

• Symbol: Thpo^{tm1.1(TPO)Flv}
• Name: thrombopoietin; targeted mutation 1.1, Richard A Flavell
• MGI ID: MGI:4887867
• Synonyms: TPO^h
• Gene: Thpo Location: Chr16:20543204-20553261 bp, - strand Genetic Position: Chr16, 12.51 cM
• Alliance: Thpo^{tm1.1(TPO)Flv} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168301
• Parent Cell Line: V17 (ES Cell)
• Strain of Origin: BALB/cAnNTac x 129S4/SvJae

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region was replaced with the corresponding human sequence. Cre-mediated recombination removed the neo cassette. (J:168301)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Thpo Mutation: 23 strains or lines available

Notes

Originally generated in ES cells containing Il2rg^tm1.1Flv and Rag2^tm1.1Flv.

References

• Original: J:168301 Rongvaux A, et al., Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2378-83
• All: 18 reference(s)