Tg(Pklr-BCL2)BAk
Transgene Detail

Summary

• Symbol: Tg(Pklr-BCL2)BAk
• Name: transgene insertion B, Axel Kahn
• MGI ID: MGI:4936850
• Transgene: Tg(Pklr-BCL2)BAk Location: unknown
• Alliance: Tg(Pklr-BCL2)BAk page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pklr-BCL2)BAk expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BCL2 (596)

  Bcl2	(MGI:88138)

• Mutation details: A human BCL2 cDNA sequence under the regulatory control of a rat Pklr promoter was used for the transgene. Rat Pklr regulatory sequences were used to drive transgene expression in hepatocytes, enterocytes, and proximal tubular cells of the kidney. The Pklr region includes the promoter, exon 1, and part of exon 2. Expression of the transgene in intestine, pancreas, liver, and kidney was confirmed by Northern and Western blot analysis. (J:81129)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Transgenic lines A (2 copies) and B (10 copies) were established. All animals from both transgenic lines exhibit no obvious phenotype

References

• Original: J:81129 Lacronique V, et al., Bcl-2 protects from lethal hepatic apoptosis induced by an anti-Fas antibody in mice. Nat Med. 1996 Jan;2(1):80-6
• All: 6 reference(s)